Non-Small Cell Lung Cancer Pipeline| 135+ Key Players & 150+ Pipeline Drugs | FDA, EMA, and PMDA Approvals, Clinical Trials

November 18 15:31 2022
Non-Small Cell Lung Cancer Pipeline| 135+ Key Players & 150+ Pipeline Drugs | FDA, EMA, and PMDA Approvals, Clinical Trials

DelveInsight’s, Non-Small-Cell Lung cancer Pipeline Insight, 2022,” report provides comprehensive insights about 135+ companies and 150+ pipeline drugs in Non-Small-Cell Lung cancer pipeline landscape. It covers the pipeline drug profiles, including clinical and nonclinical stage products. It also covers the therapeutics assessment by product type, stage, route of administration, and molecule type. It further highlights the inactive pipeline products in this space.

 

In the Non-Small-Cell Lung cancer Pipelinereport, detailed description of the drug is given which includes mechanism of action of the drug, Non-Small-Cell Lung cancer Pipelineclinical studies, NDA approvals (if any), and product development activities comprising the technology, Non-Small-Cell Lung cancer collaborations, licensing, mergers and acquisition, funding, designations and other product related details.

 

Key takeaways from the Non-Small-Cell Lung cancer Pipeline Report

  • DelveInsight’s Non-Small-Cell Lung cancer Pipeline analysis depicts a robust space with 135+ active players working to develop 150+ pipeline treatment therapies.
  • The Leading Non-small cell lung cancer companies developing novel drug candidates to improve the Non-small cell lung cancer treatment landscape include BridgeBio Pharma, Daiichi Sankyo, EMD Serono, Merck, Abbvie, Pfizer, Eli Lilly and Company, BioNTech SE, Shenzhen TargetRx, Taiho Pharmaceutical, Chong Kun Dang, Innovent Biologics, Xuanzhu Biopharmaceutical, Bayer, GeneScience Pharmaceuticals, InventisBio, Apollomics, Imugene, Ono Pharmaceutical/Pierre Fabre, Jiangsu Hengrui Medicine Co., Bristol-Myers Squibb, Surface Oncology, Inhibrx, Sinocelltech, Mirati Therapeutics, REVOLUTION Medicines, Yong Shun Technology Development, Iovance Biotherapeutics, Galecto Biotech,  and others.
  • Promising Non-small cell lung cancer pipeline therapies in various stages of development include  INBRX-106, Datopotamab deruxtecan, Bintrafusp alfa, Patritumab deruxtecan, GB 1211, BBP 398, Cofetuzumab pelidotin, Abemaciclib, BNT 116, JMT101, RMC-4630, MGY 825, Adagrasib, JDQ443, TGRX 326, CKD 702, Citarinostat, IBI 110, XZP 3621, BAY 2927088, SRF388, ABBV 514, Gentuximab injection, Befotertinib, Geptanolimab, Naporafenib, IMU-201, Binimetinib, HS 10241, APX005M, Finotonlimab, Encorafenib, Autologous tumour infiltrating lymphocytes, and others.
  • The Non-Small-Cell Lung cancer Companies and academics are working to assess challenges and seek opportunities that could influence Non-Small-Cell Lung cancer R&D. The therapies under development are focused on novel approaches to treat/improve Non-Small-Cell Lung cancer.

 

Recent Developmental Activities in the Non-small Cell Lung Cancer Pipeline

  • In Oct 2022, BerGenBio announced that they had begun the phase Ib/IIa trial evaluating bemcentinib in first-line non-small cell lung cancer patients with STK11 mutations.
  • In Oct 2022, eftilagimod alpha has been given a fast-track designation by the FDA for use as the first-line treatment for patients with stage IIIB/IV non-small cell lung cancer when combined with pembrolizumab.
  • In May 2022, BridgeBio Pharma and Bristol Myers Squibb (BMS) entered an exclusive license agreement for developing and marketing BBP-398 in oncology. An inhibitor of SHP2, BBP-398, was created through a partnership with the Therapeutics Discovery division of The University of Texas MD Anderson Cancer Center, US. Under the deal, BMS will make upfront and milestone payments of up to $905m to BridgeBio.

 

Request a sample and discover the recent breakthroughs happening NSCLC pipeline landscape @ Non-small Cell Lung Cancer Pipeline Report

 

Non-small Cell Lung Cancer Overview

Non-small-cell lung cancer is any type of epithelial lung cancer other than small-cell lung cancer (SCLC) and accounts for about 85% of all lung cancers. There are three kinds of NSCLC tumors: a) Adenocancer starts in cells inside air sacs that make mucus and other substances, often in the outer parts of your lungs. It’s the most common kind of lung cancer among both smokers and nonsmokers and people under 45. It often grows more slowly than other lung cancers. b) Squamous cell lung cancer starts in cells that line the inner airways of the lungs. About a quarter of lung cancers are this kind. c) Large cell (undifferentiated) cancer grows and spreads more quickly. That can make it tougher to treat. It’s about 10% of lung cancers. An effective treatment for non-small cell adenocancer depends on the cancer’s stage. Surgery to remove all or only part of the lung is usually required if the cancer hasn’t spread.

 

Non-Small-Cell Lung cancer Emerging Drugs 

Datopotamab deruxtecan: Daiichi Sankyo

Datopotamab deruxtecan (Dato-DXd) is an investigational TROP2 directed ADC. Designed using Daiichi Sankyo’s proprietary DXd ADC technology, datopotamab deruxtecan is one of three leading ADCs in the oncology pipeline of Daiichi Sankyo, and one of the most advanced programs in AstraZeneca’s ADC scientific platform. Datopotamab deruxtecan is comprised of a humanized anti-TROP2 IgG13 monoclonal antibody, developed in collaboration with Sapporo Medical University, attached to a number of topoisomerase I inhibitor payloads, an exatecan derivative, via tetrapeptide-based cleavable linkers. 

JDQ443: Novartis

JDQ443, an investigational selective, covalent, and orally bioavailable KRASG12C inhibitor, shows 57% confirmed ORR at recommended dose of 200 mg twice daily in Phase Ib study in patients with advanced non-small cell lung cancer (NSCLC). 

MRTX849: Mirati Therapeutics

Adagrasib (MRTX849) is an investigational, highly selective, and potent oral small-molecule inhibitor of KRASG12C that is optimized to sustain target inhibition, an attribute that could be important to treat KRASG12C-mutated cancers, as the KRASG12C protein regenerates every 24–48 hours. Adagrasib is being evaluated as monotherapy and in combination with other anti-cancer therapies in patients with advanced KRASG12C-mutated solid tumors, including NSCLC, colorectal cancer and pancreatic cancer. 

INBRX-106: Inhibrx

INBRX-106 is a hexavalent product candidate agonist of OX40. OX40 is a co-stimulatory receptor expressed on immune cells that is enriched in the tumor microenvironment. OX40 ligand is a trimeric protein that activates OX40 signaling through clustering.  INBRX-106 was engineered to bind and cluster six OX40 receptors and has been shown preclinically to significantly outperform bivalent antibodies in co-stimulatory capacity and anti-tumor activity.

 

Non-Small-Cell Lung cancer Pipeline Therapeutic Analysis

There are approx. 135+ key companies which are developing the therapies for Non-Small-Cell Lung cancer (NSCLC). The companies which have their Non-Small-Cell Lung cancer (NSCLC) drug candidates in the most advanced stage, i.e. Phase III include Daiichi Sankyo.

 

Learn more about the NSCLC emerging pipeline therapies @ Non-small Cell Lung Cancer Clinical Trials

 

Non-small Cell Lung Cancer Pipeline Therapies and Key Companies

  • Datopotamab deruxtecan: Daiichi Sankyo
  • JDQ443: Novartis
  • MRTX849: Mirati Therapeutics
  • INBRX-106: Inhibrx
  • GB 1211: Galecto Biotech
  • BBP 398: BridgeBio Pharma
  • TGRX 326: Shenzhen TargetRx
  • SRF388: Surface Oncology
  • ABBV 514: AbbVie

 

Non-small Cell Lung Cancer Pipeline Therapeutics Assessment

  • By Product Type
  • By Stage
  • By Route of Administration
  • By Molecule Type

 

Dive deep into rich insights for NSCLC emerging therapies and assessment, visit @ Non-small Cell Lung Cancer Emerging Therapies

 

 

Scope of the Non-small Cell Lung Cancer Pipeline Report

  • Coverage: Global 
  • Key Non-small Cell Lung Cancer Companies: BridgeBio Pharma (NASDAQ: BBIO), Daiichi Sankyo, EMD Serono (ETR: MRK), Merck (NYSE: MRK), Abbvie (NYSE: ABBV), Pfizer (NYSE: PFE), Eli Lilly and Company (NYSE: LLY), BioNTech SE (NASDAQ: BNTX), Shenzhen TargetRx, Taiho Pharmaceutical, Chong Kun Dang, Innovent Biologics, Xuanzhu Biopharmaceutical, Bayer (ETR: BAYN), GeneScience Pharmaceuticals, InventisBio, Apollomics, Imugene (ASX: IMU), Ono Pharmaceutical/Pierre Fabre, Jiangsu Hengrui Medicine Co., Bristol-Myers Squibb (NYSE: BMY), Surface Oncology (NASDAQ: SURF), Inhibrx (NASDAQ: INBX), Sinocelltech, Mirati Therapeutics (NASDAQ: MRTX), REVOLUTION Medicines (NASDAQ: RVMD), Yong Shun Technology Development, Iovance Biotherapeutics (NASDAQ: IOVA), Galecto Biotech (NASDAQ: GLTO), and others.
  • Key Non-small Cell Lung Cancer Pipeline Therapies: INBRX-106, Datopotamab deruxtecan, Bintrafusp alfa, Patritumab deruxtecan, GB 1211, BBP 398, Cofetuzumab pelidotin, Abemaciclib, BNT 116, JMT101, RMC-4630, MGY 825, Adagrasib, JDQ443, TGRX 326, CKD 702, Citarinostat, IBI 110, XZP 3621, BAY 2927088, SRF388, ABBV 514, Gentuximab injection, Befotertinib, Geptanolimab, Naporafenib, IMU-201, Binimetinib, HS 10241, APX005M, Finotonlimab, Encorafenib, Autologous tumour infiltrating lymphocytes, and others.

 

Table of Content

  1. Introduction
  2. Executive Summary
  3. Non-Small-Cell Lung cancer (NSCLC): Overview
  4. Pipeline Therapeutics
  5. Therapeutic Assessment
  6. Non-Small-Cell Lung cancer (NSCLC)– DelveInsight’s Analytical Perspective
  7. Mid Stage Products (Phase III)
  8. Datopotamab deruxtecan: Daiichi Sankyo
  9. Drug profiles in the detailed report…..
  10. Mid Stage Products (Phase II)
  11. RMC-4630: REVOLUTION Medicines
  12. Drug profiles in the detailed report…..
  13. Early Stage Products (Phase I/II)
  14. GB 1211: BridgeBio Pharma
  15. Drug profiles in the detailed report…..
  16. Early Stage Products (Phase I)
  17. BBP 398: BridgeBio Pharma.
  18. Drug profiles in the detailed report…..
  19. Preclinical Stage Products
  20. Drug name: Company name
  21. Drug profiles in the detailed report…..
  22. Inactive Products
  23. Non-Small-Cell Lung cancer Key Companies
  24. Non-Small-Cell Lung cancer Key Products
  25. Non-Small-Cell Lung cancer (NSCLC)- Unmet Needs
  26. Non-Small-Cell Lung cancer (NSCLC)- Market Drivers and Barriers
  27. Non-Small-Cell Lung cancer (NSCLC)- Future Perspectives and Conclusion
  28. Non-Small-Cell Lung cancer (NSCLC) Analyst Views
  29. Non-Small-Cell Lung cancer (NSCLC) Key Companies
  30. Appendix

 

Key Questions

Current Treatment Scenario and Emerging Therapies:

  • How many companies are developing Non-Small-Cell Lung cancer (NSCLC) drugs?
  • How many Non-Small-Cell Lung cancer (NSCLC) drugs are developed by each company?
  • How many emerging drugs are in mid-stage, and late-stage of development for the treatment of Non-Small-Cell Lung cancer (NSCLC)?
  • What are the key collaborations (Industry–Industry, Industry–Academia), Mergers and acquisitions, licensing activities related to the Non-Small-Cell Lung cancer (NSCLC) therapeutics?
  • What are the recent trends, drug types and novel technologies developed to overcome the limitation of existing therapies?
  • What are the clinical studies going on for Non-Small-Cell Lung cancer (NSCLC) and their status?
  • What are the key designations that have been granted to the emerging drugs?

 

For further information on the NSCLC current pipeline therapeutics, reach out to @ Non-small Cell Lung Cancer Treatment

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